Pleural Effusion and Mesothelioma: Causes Treatment and Home Management
By: Christopher M. Placitella Jun 30, 2026
Updated: July 15, 2026
Quick Answer: Pleural effusion is a buildup of fluid between the lung and chest wall, and it is a common complication of pleural mesothelioma. Doctors diagnose it with imaging and confirm it with thoracentesis, a procedure that also removes fluid to relieve symptoms. Treatment options include repeated thoracentesis, pleurodesis, an indwelling PleurX catheter, or treating the underlying cancer directly. Cohen, Placitella & Roth has represented mesothelioma patients and families for more than 40 years and offers a free consultation.
Pleural effusion is a buildup of fluid in the space between the lung and the chest wall. It is one of the most common complications our clients with pleural mesothelioma experience, and it can cause significant breathing difficulty if left untreated.
What Causes Pleural Effusion
In mesothelioma patients, tumor cells irritate the pleura and disrupt the normal balance of fluid production and absorption, causing fluid to accumulate. This is especially common in pleural mesothelioma, though it can also occur with other lung conditions.
Diagnosing Pleural Effusion
Doctors typically identify pleural effusion using a chest X-ray or CT scan, which shows the fluid buildup. A thoracentesis procedure — inserting a thin needle into the chest to withdraw fluid — both confirms the diagnosis and allows the fluid to be tested for cancer cells.
Treatment Options
- Thoracentesis — draining fluid with a needle provides temporary relief, though fluid can reaccumulate and repeat procedures may be needed
- Pleurodesis — a procedure that seals the pleural space, using a chemical or talc irritant to prevent fluid from building up again
- PleurX catheter — a small, indwelling catheter that allows patients to drain fluid at home as needed, reducing hospital visits
- Treating the underlying cancer — chemotherapy or other systemic treatment can reduce fluid production by shrinking the tumor itself
Because pleural effusion tends to recur in mesothelioma patients, your care team will likely discuss which long-term management option — repeat thoracentesis, pleurodesis, or a PleurX catheter — best fits your situation and quality-of-life goals.
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Talk to Cohen, Placitella & Roth About Your Diagnosis
Pleural effusion can be managed effectively, but it often requires an ongoing treatment plan tailored to your situation. Our mesothelioma attorneys have represented patients and families for more than 40 years. Contact Cohen, Placitella & Roth for a free consultation. Call us at (888) 324-7683 or contact us online. We work on a contingency fee basis. You pay nothing unless we recover compensation for you.
Attorney Advertising. Prior results do not guarantee a similar outcome. This article is for informational purposes only and does not constitute legal or medical advice. Consult a qualified healthcare provider regarding diagnosis and treatment, and a qualified attorney regarding your legal rights. Cohen, Placitella & Roth, P.C. is licensed to practice in New Jersey, Pennsylvania, and other jurisdictions, and represents clients nationwide with qualified co-counsel.
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