Pleural Mesothelioma: Symptoms Diagnosis and Treatment Options

By:  Christopher M. Placitella Jun 24, 2026

Updated: July 15, 2026

Quick Answer: Pleural mesothelioma forms in the pleura, the lining around the lungs, and is the most common form of the disease, accounting for approximately 75% of cases. Symptoms include shortness of breath, chest pain, a persistent cough, fatigue, weight loss, and pleural effusion. Diagnosis requires imaging plus a biopsy — thoracentesis, a needle biopsy, or thoracoscopy (VATS). Treatment may include surgery, chemotherapy, radiation, immunotherapy, or clinical trials. Cohen, Placitella & Roth has represented pleural mesothelioma patients and families for more than 40 years and offers a free consultation.

Pleural mesothelioma forms in the pleura — the thin membrane that lines the lungs and chest wall. It is the type of mesothelioma most commonly diagnosed, and the one CPR sees most often in our practice.

Symptoms of Pleural Mesothelioma

Based on what our clients report and a review of their medical records, common symptoms include:

  • Shortness of breath — difficulty breathing during activity or rest
  • Chest pain or tightness — discomfort in the chest area
  • Persistent cough — ongoing coughing that does not go away
  • Fatigue and weight loss — feeling tired and losing weight without explanation
  • Pleural effusion — fluid buildup in the chest; read more about pleural effusion and how it is managed

These symptoms can resemble minor health issues and may be overlooked. If you have a history of asbestos exposure and experience these symptoms, tell your doctor immediately.

How Pleural Mesothelioma Is Diagnosed

Doctors typically start with chest X-rays, CT scans, PET scans, and pulmonary function tests. A biopsy, however, is the only definitive test. Your doctor may use one of the following:

  • Thoracentesis — a thin needle removes excess fluid from the chest, relieving symptoms and providing cells for testing
  • Needle biopsy — a needle inserted through the chest wall collects tissue for examination
  • Thoracoscopy (VATS) — a small camera and instruments inserted through small chest incisions allow direct viewing of the pleura and offer high diagnostic accuracy

Treatment Options

Treatment for pleural mesothelioma is typically multimodal and may include:

  • Surgery — removes tumors or drains fluid to relieve symptoms or improve outcomes
  • Chemotherapy — typically cisplatin combined with pemetrexed (Alimta)
  • Radiation therapy — helps shrink tumors and relieve pain in affected areas
  • Immunotherapy — newer drugs such as nivolumab and ipilimumab that help the immune system fight the cancer
  • Clinical trials — experimental therapies being tested but not yet FDA-approved

It is completely natural to have questions for your doctor after a diagnosis — what stage the disease is at, whether you are a candidate for surgery, and whether a second opinion from a mesothelioma specialist makes sense.

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Frequently Asked Questions

  • What is pleural mesothelioma?

    Pleural mesothelioma is a cancer that forms in the pleura — the thin membrane that lines the lungs and chest wall. It is the most commonly diagnosed form of mesothelioma, accounting for approximately 75% of all cases, and is caused by asbestos fiber exposure.

  • What are the symptoms of pleural mesothelioma?

    Common symptoms include shortness of breath, chest pain or tightness, a persistent cough that doesn’t go away, unexplained fatigue and weight loss, and pleural effusion (fluid buildup in the chest). These symptoms can resemble minor health issues and may be overlooked.

  • How is pleural mesothelioma diagnosed?

    Diagnosis typically involves chest X-rays, CT scans, PET scans, and pulmonary function tests. A biopsy is the only definitive test, and options include thoracentesis, a needle biopsy through the chest wall, or thoracoscopy (VATS), which offers high diagnostic accuracy.

  • What treatments are available for pleural mesothelioma?

    Treatment options include surgery to remove tumors or drain fluid, chemotherapy using cisplatin and pemetrexed, radiation therapy, immunotherapy with nivolumab and ipilimumab, and clinical trials for experimental therapies.

Talk to Cohen, Placitella & Roth About Your Diagnosis

Pleural mesothelioma is the most common form of this disease, but every case is different. Our mesothelioma attorneys have represented patients and families for more than 40 years. Contact Cohen, Placitella & Roth for a free consultation. Call us at (888) 324-7683 or contact us online. We work on a contingency fee basis. You pay nothing unless we recover compensation for you.


Attorney Advertising. Prior results do not guarantee a similar outcome. This article is for informational purposes only and does not constitute legal or medical advice. Consult a qualified healthcare provider regarding diagnosis and treatment, and a qualified attorney regarding your legal rights. Cohen, Placitella & Roth, P.C. is licensed to practice in New Jersey, Pennsylvania, and other jurisdictions, and represents clients nationwide with qualified co-counsel.

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